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Some studies indicate that exercise may increase life expectancy and the overall quality of life. Children who have more proficient motor skills early on are more inclined to being physically active, and thus tend to perform well in sports and have better fitness levels.

Early motor proficiency has a positive correlation to childhood physical activity and fitness levels, while less proficiency in motor skills results in a tendency to partake in a more sedentary lifestyle. There is a direct correlation between physical inactivity and cardiovascular mortality, and physical inactivity is an independent risk factor for the development of coronary artery disease.

Low levels of physical exercise increase the risk of cardiovascular diseases mortality. The greatest potential for reduced mortality is in the sedentary who become moderately active. Studies have shown that since heart disease is the leading cause of death in women, regular exercise in aging women leads to healthier cardiovascular profiles.

Persons who modify their behavior after myocardial infarction to include regular exercise have improved rates of survival. Persons who remain sedentary have the highest risk for all-cause and cardiovascular disease mortality. Epidemiological evidence suggests that moderate exercise has a beneficial effect on the human immune system ; an effect which is modeled in a J curve. However, another study did not find the effect. Immune cell functions are impaired following acute sessions of prolonged, high-intensity exercise, and some studies have found that athletes are at a higher risk for infections.

Studies have shown that strenuous stress for long durations, such as training for a marathon, can suppress the immune system by decreasing the concentration of lymphocytes. Athletes may have slightly elevated natural killer cell count and cytolytic action, but these are unlikely to be clinically significant.

In individuals with heart disease, exercise interventions lower blood levels of fibrinogen and C-reactive protein, an important cardiovascular risk marker. According to the review, "[there] was consistent evidence from 27 observational studies that physical activity is associated with reduced all-cause, breast cancer—specific, and colon cancer—specific mortality.

There is currently insufficient evidence regarding the association between physical activity and mortality for survivors of other cancers. There is clear evidence of exercise treatment efficacy for major depressive disorder and attention deficit hyperactivity disorder. The Cochrane Collaboration review on physical exercise for depression noted that, based upon limited evidence, it is more effective than a control intervention and comparable to psychological or antidepressant drug therapies.

Without proper rest, the chance of stroke or other circulation problems increases, [80] and muscle tissue may develop slowly. Extremely intense, long-term cardiovascular exercise, as can be seen in athletes who train for multiple marathons, has been associated with scarring of the heart and heart rhythm abnormalities.

These changes further result in myocardial cell damage in the lining of the heart, leading to scar tissue and thickened walls. During these processes, the protein troponin increases in the bloodstream, indicating cardiac muscle cell death and increased stress on the heart itself. For many activities, especially running and cycling , there are significant injuries that occur with poorly regimented exercise schedules.

Injuries from accidents also remain a major concern, [85] whereas the effects of increased exposure to air pollution seem only a minor concern. Unaccustomed overexertion of muscles leads to rhabdomyolysis damage to muscle most often seen in new army recruits. One result of detrimental overtraining is suppressed immune function, with an increased incidence of upper respiratory tract infection URTI. While one set of joints and muscles may have the tolerance to withstand multiple marathons , another body may be damaged by 20 minutes of light jogging.

This must be determined for each individual. Too much exercise may cause a woman to cease menstruation, a symptom known as amenorrhea.


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